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DIFOPEIN

Product Name
DIFOPEIN
CAS No.
396834-58-5
Chemical Name
DIFOPEIN
Synonyms
DIFOPEIN;M.W. 6387.17 C273H424N76O89S6
CBNumber
CB6675527
Molecular Formula
C273H424N76O89S6
Formula Weight
6387.13
MOL File
396834-58-5.mol
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DIFOPEIN Property

storage temp. 
Store at -20°C
Water Solubility 
Soluble to 5 mg/ml in Water
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
255139
Product name
Difopein
Packaging
100ug
Price
$573
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PRO0000351
Product name
DIFOPEIN
Purity
95.00%
Packaging
5MG
Price
$503.48
Updated
2021/12/16
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DIFOPEIN Chemical Properties,Usage,Production

Description

Difopein is an inhibitor of 14-3-3 protein.

14-3-3 protein has been involved in a wide range of biologic processes such as signal transduction, vesicular transport, cell cycle control, DNA replication, DNA repair and apoptosis. 14-3-3 protein has been associated with tumor genesis. 14-3-3 protein correlates with reduced tumor cell apoptosis and abbreviated patient survival. Up-regulation of 14-3-3 protein provides a survival advantage to tumor cells. Inhibition of 14-3-3 protein might trigger apoptosis, inhibit growth of established tumors, suppress de novo tumor formation, and promise a novel therapeutic approach for glioma treatment [1].

In human glioma U251 and U87 cells, difopein resulted in apoptosis characteristics, such as nuclear fragmentation, DNA laddering fragment and appearance of membrane-enclosed apoptotic bodies. Difopein induced apoptosis in a time-dependent manner [1]. Difopein induced glioma cell apoptosis through down-regulating Bcl-2, up-regulating Bax and activating caspase-9 and caspase-3. In vivo, difopein effectively hindered proliferation and triggered apoptosis of tumor cells implanted into nude mice [1].

References

[1] Cao W, Yang X, Zhou J, et al.  Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice[J]. Apoptosis, 2010, 15(2): 230-241.

DIFOPEIN Preparation Products And Raw materials

Raw materials

Preparation Products

396834-58-5, DIFOPEINRelated Search:


  • M.W. 6387.17 C273H424N76O89S6
  • DIFOPEIN
  • 396834-58-5
  • C273H424N76O89S6
  • Caspases/Apoptosis